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By - Pomme-M
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- Author: u/Pomme-M URL: https://www.cell.com/structure/fulltext/S0969-2126(23)00166-1 *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
I have an autoimmune disease. 0/10 would not recommend.
What? You don't want to "boost" your immune system? When I see products that claim that, I think >It's a good thing this doesn't work.
So is this applicable to all autoimmune conditions?
Can anyone with a little more knowledge about immune diseases fill me in on whether this would work for something like autoimmune liver like primary sclerosing cholangitis, or if it would be restricted to usefulness in stuff like MS, ulcerative colitis and Crohn's disease? I know Celiac disease is more immune-mediated, but could it see some effect there? Basically, what is the scope of diseases this could potentially treat?
It's overall in very early stages of turning into effective medication for anything, but it does state promise for "auto-immune related inflammatory disorders" and was particularly shown effective in a mouse model with induced psoriasis. So, hard to say how broadly it could be applied in the world of autoimmune diseases until further trials.
BTLA, the target of this therapy, is very important for the pathogenesis of several respiratory inflammatory disorders like asthma. Eli Lily is hoping that using BTLA as a target will open up a ton of doors for modulating negative immune responses across numerous pathologies. It’s being tested, currently, in Lupus.
For only $170,000 a year! (It’s a joke, but probably a prescient one)
Per pill is more likely
As a person with a (stage 4) severe uncontrolled bronchial asthma I'm really looking forward to it.