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Alcoholicmisanthrope

Once bile acids and lipase act on the meal I can’t see how it would make a significant difference. As long as the fat and vitamin D are present in the small intestine at the same time the differences would be minimal. I don’t think you will find a source that answers this specific question so I don’t have a link, I’ll delete my post if someone posts a proper answer.


MannedUAV

Not what you are asking, but you can get capsules with e.g. olive oil which removes the need to take it with fatty foods


themainheadcase

I'm being treated in a national health system, so I'm sadly stuck with whatever the doctor writes a prescription for.


MannedUAV

For your question I would think it doesn’t matter since the stomach would split up the ingredients. The guy who taught me about taking VitD with fats has a background in nutritional chemistry and he said “take it fatty encapsulated or with a meal” AFAIR


neddoge

>take it fatty encapsulated or with a meal Indeed. This is the only advice needed re: VitD.


Delimadelima

Michael Greger has a video where he cites a paper showing that vitamin D absorption is ~20% less without accompanying fat. Given that many people seem to overdose on vitamin D (~500%) I wouldn't be bothered at all about the absorption difference.


[deleted]

[удалено]


rfifjf90

https://sci-hub.se/10.1093/nutrit/nux034


themainheadcase

Good find, but I perused it and it doesn't seem to address that particular point.


rfifjf90

This study seems to suggest that type of fat doesn't really matter: https://sci-hub.se/10.1016/j.jand.2014.09.014


themainheadcase

But their two groups were eating olive oil and corn oil, respectively, so both were taking the supplement with liquid fat.


rfifjf90

True. Check out the second paper I sent. It mentions vitamin D being taken with some foods and beverages. My takeaway from it was that food type doesn't make a huge difference.


rfifjf90

Also check this out: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643801/


themainheadcase

Hmmm... this one seems to cast doubt on the whole idea that fat aids absorption (under the heading "Amount of lipids (triglycerides)"). Perhaps because the studies they list feature meals with too little fat? One study I read suggested at least around 15g may be necessary.


rfifjf90

Does this study settle it then? :) https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/23427007/


Balthasar_Loscha

The amount of lipids matter, because the presence of lipid induces expression of chylomicrons, which are then used for trafficking of vD.