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November 24 preprint that has a total of 524 tweets per Biorxiv. Similar preprints from 11/23, 11/24 have 10-20max. Sad state of misinformation right now.


Ugh I loathe in vitro binding experiments, just because folks tend to read far too much into them. (And also because it’s not that hard to trigger certain things in the dish.) One rule of thumb is to always to check the concentrations. If nothing happens below a certain threshold and you only see an effect at relatively high doses that simply aren’t physiologically achievable in the blood, then it’s highly unlikely to happen in an actual human being, no matter what you see in a dish. And that’s probably the case here, both with the agglutination and with the ivermectin treatment. And in fact, we already know this about ivermectin, since this “concentration not physiologically possible” was precisely the noted issue when comparing early in vitro assays to lack of real-world efficacy. (I also dunno why they’re bringing up animal modeling in the first paragraph of their discussion, but not carrying out any sort of in vivo testing themselves. But that’s more of a pet peeve.)


Buying the lede on this one. The research also found that Ivermectin counters the spike protein hemagglutination. This validates what people in this sub were saying two years ago; Ivermectin might reduce some of the symptoms of COVID while doing nothing at all to help you clear the virus. All of that to be taken with grains of salt, anyhow, as this article is yet to get through review.


>In the HA inhibition experiment, IVM added to 2.5% RBC solution to attain a concentration of at 1 μM at 30 minutes prior to spike protein partially inhibited HA, with HA observed at a spike protein concentration of 2.12 ng/μL for the Wuhan, Alpha and Delta and of 0.27 ng/μL for the Omicron viral lineages. With IVM at 2 μM, complete inhibition of HA is observed for the Wuhan, Alpha and Delta lineages. For Omicron, IVM at 4μM is needed to totally block HA. 1 uM is many times above concentrations achievable with maximum tolerated doses in humans. This is irrelevant. https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.1889


Ah, you are correct, I missed that detail.


Not your fault, the authors - they fall over themselves in the Discussion trying to justify it but it is unjustifiable. Use physiologically relevant doses or not at all.


IVM is an anti-inflammatory, so it doesn’t surprise anyone that it might make some patients feel better. But we have better anti-inflammatories, and there is too much sketchy special interest involved with the IVM/HCQ/etc. push.


Can you share some evidence that all anti-inflammatories prevent/reduce hemagglutination? Especially evidence specific to hemagglutination involving the spike protein?




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