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zwischen3und20

Could it be related to mast cell activation? Some googling indicates just that: IgE plays a vital role in the crosstalk between innate and adaptive immunity. It is involved in allergic reactions via the sensitization of mast cells.Activation of mast cells occurs after antigen binding of IgE resulting in the release of histamine, lipid mediators, and cytokines https://www.sigmaaldrich.com/NO/en/technical-documents/technical-article/research-and-disease-areas/immunology-research/anti-human-antibodies-covid-19-sars-cov-2-immunoglobulin-detection#IgEClass Or could it be covid antibody related? I have had covid at least once, btw.


zwischen3und20

Asking out of curiosity: why is the parent comment downvoted? 😥


The_Re_Face

I don't know a lot about the subject, but high expression of specifically IgE antibodies is often associated with Type I Hypersensitivity. [https://en.wikipedia.org/wiki/Type\_I\_hypersensitivity](https://en.wikipedia.org/wiki/Type_I_hypersensitivity)


zwischen3und20

Thanks for sharing. This actually fits well with other symptoms, like the vague allergies I have from time to time. Thanks again, I think your link is a very important piece in my everlasting puzzle.


bio-nerd

My first instinct is to double check the units - make sure the article you're reading is comparable to your results (and usually arbitrary units are not interchangeable unless they use the same test). Usually a blood panel will also report the range of detection and what values match with certain diagnostic criteria, so see if you can look at the full report with your physician to see where yours fall.


thegreatparnassus

Hey I would say wrong sub. maybe try r/immunology. I can try to lend a bit of info as a 1st year med student. IgE is a type of antibody. People often associate it with allergies and here's why. It floats around in your body until a mast cell grabs onto it. While holding onto IgE, if an allergy binds to IgE, the mast cell screams there's allergies! And releases a bunch of histamine that causes the symptoms you experience as allergies. So if there is more IgE floating around, you likely will have what we all sensitized mast cells (those ready to release histamine) and are more likely to experience allergies when you encounter that allergen.


zwischen3und20

Sorry for posting to the wrong sub. Thanks for your reply. It resonates well with my current main hypothesis, that my problems are somewhat connected to mast cells. Mast cell activation syndrome, MCAS, is a thing, isn't it? As for allergies, I frequently feel like shit after meals, depending on meal frequency and content. Rib-eyes are fine, bread and pizzas not so much. I think that some foods cause the mast cells to activate for no good reason. This runs in the family too, so maybe genetic? My physician and I have been conducting a small diagnostic experiment to see if lorazepam calms the mast cells(which have receptors for some benzos). It seems to work well as the stomach pain and the low mood I experience straight after meals, disappears. I am a bit scared of benzos, and haven't tried taking it prior to meals. Thanks to everyone who replied. I'm just a patient with zero formal knowledge about this topic and truly appreciate any help I can get.


thegreatparnassus

It's good you are staying curious about what is going on inside of you. That sounds like a good plan. Work with your physician on slowly figuring out what triggers it and if you can de-sensitize those mast cells so it happens less frequently. I feel like problems like this are not solved quickly, and that is because everybody is so unique with regards to their allergies. Hang in there and keep trying to solve it. Things will get better!


joash_the

IgE is associated with allergies, so if it's elevated, perhaps you may have had a reaction to something recently. Maybe even something you pass off as a cold. Do you have asthma by any chance? I'm not so sure about the meaning of the values there. Perhaps you need to double check if your values are for the same unit such as IU/mL or IU/L).


zwischen3und20

I do have asthma, yes. It comes and goes depending on diet. I used to use Cymbicort for years. Ditching bread and grains helped a lot. I've asked my physician about the values, but probably won't receive any reply until February. Also, I live in a small country without access to lots of specialists. We're just not enough people over here, so I am desperately trying to figure out what's wrong. That's pretty much bound fail, given my lack of knowledge and test equipment. But still, if I don't try, no one else will.


joash_the

Your asthma might be contributing to the high IgE value, but I'm not sure if that's a typical value. Sounds like maybe an allergy to wheat also? I can't say for certain... a lot of these bodily functions/test results need to be interpreted as a whole, and compared to your baseline like your previous blood tests.


katichichori

You probably have allergies. I had the similar readings. What was your eosinophil count? Also go to an immuno or medico sub.


Hartifuil

Your value doesn't have reported volume. Are they reporting per mL or per L? That would explain why they're reporting with 10E3. As for interpreting the results, that's something only your doctor can do.


zwischen3und20

The report did not state volume. Or maybe it did, but that the units were hidden. I tried to post a copy of the values to show that there were layout issues, but that failed. The measured value, "21 x 10E3 IU" , was way wider than other values, and the U was only partially visible, so maybe the unit part was truncated? My physician will probably have access to the raw data. She'll figure it out, I hope.


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zwischen3und20

- Not in the US(Europe) - broad spectrum, as in test as much as possible. The reason is that I used to have very low values for lots of critical vitamins and minerals. - blood - I'm working with a physician trying to figure out what's wrong with me. It's definitely related to food and digestion, among other things. - sorry, but I don't understand your last question. The test was to recheck that I now have normal levels, so "checking therapeutic levels"? I'm happy for all responses, even minor details can be the solution for my problems. I do hang out in other subs as well, but in those, there are mostly patients and seldom any experts. FWIW, I'm waiting for a full genome test, which hopefully will add more information.